Chandipura virus is an enveloped RNA virus with an approximate genome length of ~11 kb. Viral genome codes for five polypeptides, namely, Nucleocapsid protein N, Phosphoprotein P, Matrix protein M, Glycoprotein G and Large protein L in five monocistronic mRNAs. N protein encapsidates genome RNA into a nuclease resistant form to protect in from cellular RNAse function. L and P protein together forms viral RNA dependent RNA polymerase; where catalytic functions for RNA polymerization, Capping and Poly-A polymerase resides within the L protein and P acts as a transcriptional activator. Matrix protein glues the encapsidated genome RNA, also known as nucleocapsid, with the outer membrane envelop. G protein spikes out of the membrane and acts as a major antigenic determinant.

No computational functional analysis of different proteins of Chandipura virus is available till date. Knowledge about protein function is essential in the understanding of biological processes .Different protein functions and molecular analysis facilitates for finding potential anti-viral inhibitors. One approach for function prediction is to classify a protein into functional family. Support vector machine (SVM) is useful method for such classification, which may involve proteins with diverse sequence distribution . Cloning and expression of different proteins practiced by molecular biologist will be helped by in silico restriction site analysis in the database.

 

Funding:-	For suggestions and comments:-
Financial support for CHPVDB is from Indian Council of Medical Research,Govement of India.	Manas Ranjan Dikhit